Mexican Health Minister Jose Angel Cordova raised the probable death toll from the new multi-strain swine flu in Mexico to 81, including 20 already confirmed.
"This virus has clearly a pandemic potential," World Health Organization director general, Margaret Chan, said on Saturday.
The Geneva-based UN agency branded the outbreak "a public health emergency of international concern," following a meeting of its emergency committee.
In Mexico, 13 new suspect cases were reported in the past 24 hours and a total of 1,324 patients with flu symptoms were under investigation, Health Minister Cordova said.
The Mexico government has upped emergency measures that were put into place only on Friday.
Officials have canceled hundreds of public events and closed schools for millions of students in and around the capital.
Many Mexico City residents wore freely-distributed surgical masks on the streets Saturday, after authorities urged people to avoid contact in public.
The government also assured citizens it had "sufficient" funds reaching 450 million dollars to combat the epidemic.
Across the northern border, health authorities in the central US state of Kansas confirmed two cases of swine flu on Saturday, bringing the total number of cases in the United States to at least 10.
One of the patients had recently traveled to Mexico.
"Both persons ... became ill with the same unique (H1N1) strain of swine flu that has been identified in Mexico, California and Texas," Kansas officials said in a statement read.
Earlier on Saturday New York officials said eight to nine students at a New York City school were suspected of having swine flu, although test results are still pending.
Meanwhile, a British Airways cabin crew staff member was being treated in a London hospital with "flu-like symptoms" after arriving on a flight from Mexico City, health officials said Saturday.
Asian health officials went on alert and urged the public to be vigilant Sunday.
In New Zealand, a 25-strong school group was quarantined pending the results of medical tests after returning from Mexico with flu-like symptoms, local health authorities said.
In Japan, airports tightened checks on passengers arriving from Mexico, with quarantine officials giving out face masks and using thermography imaging cameras to screen for passengers with a fever.
• Deaths: 86, all in Mexico. 22 confirmed as swine flu, 64 suspected.
• Sickened: 1,384 in Mexico, suspected or confirmed; 20 confirmed in U.S.; 6 confirmed in Canada; 13 suspected in New Zealand; 7 suspected in Spain; 1 suspected in France; 1 suspected in Israel; 1 suspected in Brazil.
• Locations in Mexico: 17 states, including Mexico City, Mexico State, Veracruz, Oaxaca, Baja California and San Luis Potosi. Some, including Oaxaca, Mexico City and Baja California, have tourist areas, but authorities have not said where in these states the outbreaks occurred.
• Locations in U.S.: 8 in New York, 7 in California, 2 in Kansas, 2 in Texas and 1 in Ohio.
• Safety measures in Mexico: In Mexico City, surgical masks given to subway passengers, public events canceled, schools and public venues closed and church services postponed. President Felipe Calderon has assumed new powers to isolate infected people. World Bank is providing Mexico with more than $200 million in loans to help with the outbreak.
• Safety measures in U.S: Roughly 12 million doses of Tamiflu being moved from federal stockpile to be delivered to states. Travelers at border asked about travel to flu-stricken areas. St. Francis Preparatory School in New York, where eight cases are confirmed, closed Monday and Tuesday. St. Mel's Catholic School in Fair Oaks, Calif., closed until at least Thursday as officials investigate possible infection of seventh grader.
• Safety measures worldwide: Airports screening travelers from Mexico for flu symptoms. China, Russia and Taiwan plan to put anyone with symptoms under quarantine. Hong Kong and South Korea warn against travel to Mexican City and three provinces. Italy, Poland and Venezuela advised citizens to postpone travel to affected areas of Mexico and the United States. Some countries increasing screening of pigs and pork imports or banning them outright.
Like most governments in the region, Australia urged people who had recently returned from Mexico and had developed flu-like symptoms to seek medical advice.
South Korean health, agriculture and foreign ministry officials held an emergency meeting to discuss the issue, while in China, the health ministry said it was "paying close attention" to the situation.
The CDC said some Mexican victims had died from the same new strain of swine flu that affected eight people in Texas and California.
Dave Daigle, of the CDC, said a bird flu strain, two swine flu strains and a human strain had combined for the first time.
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